Introduction

The condition of dermatitis is caused by an overgrowth of skin bacteria called Cutibacterium Acne, which results in small pimples.

Limitations of Current Treatments

While there are ways to limit bacterial growth, such as antibiotics or hormones that reduce the sebum that feeds germs, many of them have side effects or become ineffective as the bacteria adapt.

A New Drug Based on Naracin

Therefore, scientists have created a new drug based on the antibiotic Naracin, which is usually used to prevent infections in livestock and poultry and allows the treatment of cutibacteria that have not yet developed resistance to it.

Study Results

In a study conducted by researchers from the University of South Australia, the University of Adelaide in Australia and the University of Aix-Marseille in France, the antibiotic was found to be effective against the target pathogen in vitro.

Improved Treatment with Nanoparticles

In addition, the research team was able to demonstrate that delivery of nanoparticles could significantly improve treatment.

Rolled into tiny capsules a thousand times smaller than a single strand of human hair, called nanoparticles, Narasin can penetrate the skin much deeper than when mixed with plain water.

Enhanced Solubility with Nanoparticles

The team found that the nanoparticle delivery system improved solubility by more than 100-fold compared to a simple water mixture. This is due in part to the use of Soluplus, a compound that improves the solubility of nanomicelles and the stability of drug delivery.

Efficient Delivery to Target Areas

“The micellar formulation was effective in delivering narasin to target acne areas, unlike the combination solution, which was unable to penetrate the skin layers,” says pharmaceutical scientist Sanjay Garg from the University of South Australia.

Potential for Acne Treatment

Although the researchers used pig ear skin to conduct the experiments, for real acne the drug must reach the hair follicles under the skin where acne bacteria thrive.

The next step is to see how effectively the treatment works in people, but early signs are encouraging: Based on these results, Narasin’s nanogel can penetrate deep into the places where pimples hide and cause serious damage to bacteria.

Stability and Availability

The resulting gel remained stable at room temperature for four weeks. This is another good sign that the treatment is ready to use.

Publication and Source

Publish your research in a journal Nanoscale.

Source: ScienceAlert